My own observation is that Reb A by itself is far inferior to a mixture of multiple of steviosides. I tried some pure Reb A and threw it away because it was so much worse tasting than other products. This shouldn’t be a big surprise, because we generally find when using alternative sweeteners that mixtures are better. In other words, erythritol+stevia is better than either one alone. So why should it be any different with the steviosides? I wonder if this maximum sweetness issue is addressed using mixtures? I am generally able to make my ice creams and other sweet preparations sweet enough (for me) with stevia alone.
In a Phase 2 HPA clinical study [see Pharmacodynamics ], pharmacokinetics was evaluated in a subgroup of 12 adult subjects. On Day 8, blood was taken just prior to and at 1, 2, 4, 6, 8, and 12 hours following the last application. Plasma concentration of halobetasol propionate was measureable in all subjects. Based on the geometric mean plasma concentrations at 12 hour post-application across time, steady-state was achieved by Day 8. The mean (±standard deviation) Cmax concentrations for ULTRAVATE lotion on Day 8 was ± pg/mL, with the corresponding median Tmax value of 3 hours (range 0 – 6 hours); mean area under the halobetasol propionate concentration versus time curve over the dosing interval (AUCτ) was 1632 ± 1147 pg•h/mL.