IVIg treatment has advantages over plasmapheresis because it is easier to administer, has significantly fewer complications, and is more comfortable for the patient. IVIg is recommended for patients with GBS who cannot ambulate without assistance within two to four weeks of neuropathic symptom onset. 26 , 28 Modulation of the immune system is thought to occur through multiple mechanisms involving the constant and variable regions of immunoglobulin class G (IgG), as well as receptors on macrophages and B cells. Pathologic antibodies might be bound by the IgG increasing their clearance. In addition, CD8 + T cell function is enhanced by an unknown mechanism. 32
CSF is commonly used and quite successful for the findings and evidences of Guillain Barre Syndrome. Average CSF findings contain information and details of albumino-cytological dissociation. Compared to infectious symptoms, CSF is a high level protein 100 – 1000 mg/dL instead of the supplementary pleocytosis. Continuous usage of the pleocytosis may boost the immune system to resist the infections. Research has proven that high quantity of protein and pleocytosis in the CSF is essential for the diffusion of white blood cells in the myelin. In early stages of Guillain Barre Syndrome anti-inflammatory drugs and painkillers combined to offer instant relief in severe pain. Often doctors suggest blood thinners to control and prevent blood clotting.
In Guillain-Barré syndrome, the immune system starts to destroy the myelin sheath that surrounds the axons of many peripheral nerves, or even the axons themselves. The myelin sheath surrounding the axon speeds up the transmission of nerve signals and allows the transmission of signals over long distances. In diseases in which these myelin sheaths are injured or degraded, the nerves cannot transmit signals efficiently. That is why the muscles begin to lose their ability to respond to commands from the brain that must be carried through the nerve network. The brain also receives fewer sensory signals from the rest of the body, resulting in an inability to feel textures, heat, pain, and other sensations. Alternately, the brain may receive inappropriate signals that result in tingling, “crawling-skin,” or painful sensations known as paresthesias. Because the signals to and from the arms and legs must travel the longest distances, they are most vulnerable to interruption. Therefore, muscle weakness and tingling sensations usually first appear in the hands and feet and progress upwards.