All bets are off the table when high-dose testosterone and its many metabolites are used illegally, such as with anabolic steroid abuse. Strokes, embolisms, and cardiovascular disease are all more likely, as is sudden death, and liver and kidney disease. 44 In women, acne, irreversible deepening of the voice, baldness, increased facial hair, enlarged sex organs, breast reduction, depression, and infertility have all been reported. In adult men that abuse anabolic steroids, acne, baldness, permanent infertility, gynecomastia, loss of libido, erectile dysfunction, testicle shrinkage, and profuse sweating are all reported side effects. Increased testicular cancer hasn't been reported, though. 45,46
The benefits of ashwagandha are not limited to reduced stress levels. Several studies have also found out that on infertile subjects, ashwagandha is very effective at restoring poor sperm quality, while also boosting lagging testosterone production ( study , study , study ). One particularly interesting study that came out at the end of 2015, had 57 young and perfectly healthy men as test subjects. The guys consumed 300mg’s of KSM-66 ashwagandha on a daily basis for 8 weeks, and on average their T-levels increased from 630 ng/dL to 726 ng/dL .