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While whey protein appears to be more potent at stimulating protein synthesis (68% above baseline by whey, 31% by casein) whey protein fails to inhibit protein breakdown while casein can reduce protein oxidation by 31%. [75] The net result is either similar accumulations in muscle tissue content after ingestion of equal amounts of whey or casein protein, [76] or better retention with casein over 7 hours if nothing else is ingested; [76] this is despite 30% greater leucine uptake into muscle cells when measured at 2 hours post ingestion relative to casein . [76] One study that divided protein synthesis rates into a 60-210 minute period and a 210-360 minute period noted that whey increased protein synthesis significantly more than casein in the first period only, with the opposite result occurring in the latter period and no overall difference over the 5 hours tested, although casein trended towards being more effective. [77]

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Rapamycin is used clinically as an immunosuppressant and prevents the proliferation of T cells and B cells. [68] Paradoxically, even though rapamycin is a federally approved immunosuppressant , its inhibition of mTORC1 results in better quantity and quality of functional memory T cells . mTORC1 inhibition with rapamycin improves the ability of naïve T cells to become precursor memory T cells during the expansion phase of T cell development . [69] This inhibition also allows for an increase in quality of these memory T cells that become mature T cells during the contraction phase of their development. [70] mTORC1 inhibition with rapamycin has also been linked to a dramatic increase of B cells in old mice, enhancing their immune systems . [66] This paradox of rapamycin inhibiting the immune system response has been linked to several reasons, including its interaction with regulatory T cells . [70]

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